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“Dual Disease” TgAD/GSS mice exhibit enhanced Alzheimer’s disease pathology and reveal PrP(C)-dependent secretion of Aβ
To address the question of cross-talk between prion protein (PrP) and Alzheimer’s disease (AD), we generated TgAD/GSS mice that develop amyloid-β (Aβ) plaques of AD and PrP (specifically mutated PrP(A116V)) plaques of Gerstmann-Sträussler-Scheinker disease (GSS) and compared plaque-related features...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6562043/ https://ncbi.nlm.nih.gov/pubmed/31189938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44317-w |
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