Immunodetection of disease-associated mutant PrP, which accelerates disease in GSS transgenic mice

The absence of infectivity-associated, protease-resistant prion protein (PrP(Sc)) in the brains of spontaneously sick transgenic (Tg) mice overexpressing PrP linked to Gerstmann–Sträussler Scheinker syndrome, and the failure of gene-targeted mice expressing such PrP to develop disease spontaneously,...

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Main Authors: Nazor, Karah E, Kuhn, Franziska, Seward, Tanya, Green, Mike, Zwald, Daniel, Pürro, Mario, Schmid, Jaqueline, Biffiger, Karin, Power, Aisling M, Oesch, Bruno, Raeber, Alex J, Telling, Glenn C
Formato: Artigo
Idioma:Inglês
Publicado: 2005
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1173157/
https://ncbi.nlm.nih.gov/pubmed/15962001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600717
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