Analysis of the Human Kinome and Phosphatome by Mass Cytometry Reveals Overexpression-Induced Effects on Cancer-Related Signaling

Kinase and phosphatase overexpression drives tumorigenesis and drug resistance. We previously developed a mass-cytometry-based single-cell proteomics approach that enables quantitative assessment of overexpression effects on cell signaling. Here, we applied this approach in a human kinome- and phosp...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell
Prif Awduron: Lun, Xiao-Kang, Szklarczyk, Damian, Gábor, Attila, Dobberstein, Nadine, Zanotelli, Vito Riccardo Tomaso, Saez-Rodriguez, Julio, von Mering, Christian, Bodenmiller, Bernd
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cell Press 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561723/
https://ncbi.nlm.nih.gov/pubmed/31101498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.04.021
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