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Influence of node abundance on signaling network state and dynamics analyzed by mass cytometry

Signaling networks are key regulators of cellular function. Although the concentrations of signaling proteins are perturbed in disease states, such as cancer, and are modulated by drug therapies, our understanding of how such changes shape the properties of signaling networks is limited. Here we cou...

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Détails bibliographiques
Publié dans:Nat Biotechnol
Auteurs principaux: Lun, Xiao-Kang, Zanotelli, Vito RT, Wade, James D, Schapiro, Denis, Tognetti, Marco, Dobberstein, Nadine, Bodenmiller, Bernd
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617104/
https://ncbi.nlm.nih.gov/pubmed/28092656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3770
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