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Influence of node abundance on signaling network state and dynamics analyzed by mass cytometry

Signaling networks are key regulators of cellular function. Although the concentrations of signaling proteins are perturbed in disease states, such as cancer, and are modulated by drug therapies, our understanding of how such changes shape the properties of signaling networks is limited. Here we cou...

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Lun, Xiao-Kang, Zanotelli, Vito RT, Wade, James D, Schapiro, Denis, Tognetti, Marco, Dobberstein, Nadine, Bodenmiller, Bernd
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617104/
https://ncbi.nlm.nih.gov/pubmed/28092656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3770
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