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Influence of node abundance on signaling network state and dynamics analyzed by mass cytometry

Signaling networks are key regulators of cellular function. Although the concentrations of signaling proteins are perturbed in disease states, such as cancer, and are modulated by drug therapies, our understanding of how such changes shape the properties of signaling networks is limited. Here we cou...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Nat Biotechnol
Hauptverfasser: Lun, Xiao-Kang, Zanotelli, Vito RT, Wade, James D, Schapiro, Denis, Tognetti, Marco, Dobberstein, Nadine, Bodenmiller, Bernd
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617104/
https://ncbi.nlm.nih.gov/pubmed/28092656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3770
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