Clonal Vγ6(+)Vδ4(+) T cells promote IL-17–mediated immunity against Staphylococcus aureus skin infection

T cell cytokines contribute to immunity against Staphylococcus aureus, but the predominant T cell subsets involved are unclear. In an S. aureus skin infection mouse model, we found that the IL-17 response was mediated by γδ T cells, which trafficked from lymph nodes to the infected skin to induce ne...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Marchitto, Mark C., Dillen, Carly A., Liu, Haiyun, Miller, Robert J., Archer, Nathan K., Ortines, Roger V., Alphonse, Martin P., Marusina, Alina I., Merleev, Alexander A., Wang, Yu, Pinsker, Bret L., Byrd, Angel S., Brown, Isabelle D., Ravipati, Advaitaa, Zhang, Emily, Cai, Shuting S., Limjunyawong, Nathachit, Dong, Xinzhong, Yeaman, Michael R., Simon, Scott I., Shen, Wei, Durum, Scott K., O’Brien, Rebecca L., Maverakis, Emanual, Miller, Lloyd S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561199/
https://ncbi.nlm.nih.gov/pubmed/31088972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818256116
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