Clonal Vγ6(+)Vδ4(+) T cells promote IL-17–mediated immunity against Staphylococcus aureus skin infection

T cell cytokines contribute to immunity against Staphylococcus aureus, but the predominant T cell subsets involved are unclear. In an S. aureus skin infection mouse model, we found that the IL-17 response was mediated by γδ T cells, which trafficked from lymph nodes to the infected skin to induce ne...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Marchitto, Mark C., Dillen, Carly A., Liu, Haiyun, Miller, Robert J., Archer, Nathan K., Ortines, Roger V., Alphonse, Martin P., Marusina, Alina I., Merleev, Alexander A., Wang, Yu, Pinsker, Bret L., Byrd, Angel S., Brown, Isabelle D., Ravipati, Advaitaa, Zhang, Emily, Cai, Shuting S., Limjunyawong, Nathachit, Dong, Xinzhong, Yeaman, Michael R., Simon, Scott I., Shen, Wei, Durum, Scott K., O’Brien, Rebecca L., Maverakis, Emanual, Miller, Lloyd S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561199/
https://ncbi.nlm.nih.gov/pubmed/31088972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818256116
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