Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy

Cancer-associated fibroblasts (CAFs) can either suppress or support T lymphocyte activity, suggesting that CAFs may be reprogrammable to an immunosupportive state. Angiotensin receptor blockers (ARBs) convert myofibroblast CAFs to a quiescent state, but whether ARBs can reprogram CAFs to promote T l...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Chauhan, Vikash P., Chen, Ivy X., Tong, Rong, Ng, Mei Rosa, Martin, John D., Naxerova, Kamila, Wu, Michelle W., Huang, Peigen, Boucher, Yves, Kohane, Daniel S., Langer, Robert, Jain, Rakesh K.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561160/
https://ncbi.nlm.nih.gov/pubmed/31040208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1819889116
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