Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy

Cancer-associated fibroblasts (CAFs) can either suppress or support T lymphocyte activity, suggesting that CAFs may be reprogrammable to an immunosupportive state. Angiotensin receptor blockers (ARBs) convert myofibroblast CAFs to a quiescent state, but whether ARBs can reprogram CAFs to promote T l...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chauhan, Vikash P., Chen, Ivy X., Tong, Rong, Ng, Mei Rosa, Martin, John D., Naxerova, Kamila, Wu, Michelle W., Huang, Peigen, Boucher, Yves, Kohane, Daniel S., Langer, Robert, Jain, Rakesh K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561160/
https://ncbi.nlm.nih.gov/pubmed/31040208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1819889116
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