Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy

Cancer-associated fibroblasts (CAFs) can either suppress or support T lymphocyte activity, suggesting that CAFs may be reprogrammable to an immunosupportive state. Angiotensin receptor blockers (ARBs) convert myofibroblast CAFs to a quiescent state, but whether ARBs can reprogram CAFs to promote T l...

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書目詳細資料
發表在:Proc Natl Acad Sci U S A
Main Authors: Chauhan, Vikash P., Chen, Ivy X., Tong, Rong, Ng, Mei Rosa, Martin, John D., Naxerova, Kamila, Wu, Michelle W., Huang, Peigen, Boucher, Yves, Kohane, Daniel S., Langer, Robert, Jain, Rakesh K.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2019
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PNAS Plus
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561160/
https://ncbi.nlm.nih.gov/pubmed/31040208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1819889116
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