Structure, function and biosynthetic origin of octapeptin antibiotics active against extensively drug-resistant Gram-negative bacteria

Resistance to the last-resort antibiotic colistin is now widespread and new therapeutics are urgently required. We report the first in toto chemical synthesis and pre-clinical evaluation of octapeptins, a class of lipopeptides structurally related to colistin. The octapeptin biosynthetic cluster con...

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Publicado en:Cell Chem Biol
Main Authors: Velkov, Tony, Gallardo-Godoy, Alejandra, Swarbrick, James D., Blaskovich, Mark. A. T., Elliott, Alysha G., Han, Meiling, Thompson, Philip E., Roberts, Kade D., Huang, Johnny X., Becker, Bernd, Butler, Mark S., Lash, Lawrence H., Henriques, Sónia Troeira, Nation, Roger L., Sivanesan, Sivashangarie, Sani, Marc-Antoine, Separovic, Frances, Mertens, Haydyn, Bulach, Dieter, Seemann, Torsten, Owen, Jeremy, Li, Jian, Cooper, Matthew A.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6560181/
https://ncbi.nlm.nih.gov/pubmed/29396290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.01.005
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