Structure, function and biosynthetic origin of octapeptin antibiotics active against extensively drug-resistant Gram-negative bacteria

Resistance to the last-resort antibiotic colistin is now widespread and new therapeutics are urgently required. We report the first in toto chemical synthesis and pre-clinical evaluation of octapeptins, a class of lipopeptides structurally related to colistin. The octapeptin biosynthetic cluster con...

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Bibliografski detalji
Izdano u:Cell Chem Biol
Glavni autori: Velkov, Tony, Gallardo-Godoy, Alejandra, Swarbrick, James D., Blaskovich, Mark. A. T., Elliott, Alysha G., Han, Meiling, Thompson, Philip E., Roberts, Kade D., Huang, Johnny X., Becker, Bernd, Butler, Mark S., Lash, Lawrence H., Henriques, Sónia Troeira, Nation, Roger L., Sivanesan, Sivashangarie, Sani, Marc-Antoine, Separovic, Frances, Mertens, Haydyn, Bulach, Dieter, Seemann, Torsten, Owen, Jeremy, Li, Jian, Cooper, Matthew A.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6560181/
https://ncbi.nlm.nih.gov/pubmed/29396290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.01.005
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