Mutations in Na(V)1.5 Reveal Calcium-Calmodulin Regulation of Sodium Channel

Mutations in the SCN5A gene, encoding the cardiac voltage-gated sodium channel Na(V)1.5, are associated with inherited cardiac arrhythmia and conduction disease. Ca(2+)-dependent mechanisms and the involvement of β-subunit (Na(V)β) in Na(V)1.5 regulation are not fully understood. A patient with seve...

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Udgivet i:Front Physiol
Main Authors: Nof, Eyal, Vysochek, Leonid, Meisel, Eshcar, Burashnikov, Elena, Antzelevitch, Charles, Clatot, Jerome, Beinart, Roy, Luria, David, Glikson, Michael, Oz, Shimrit
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Physiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6560087/
https://ncbi.nlm.nih.gov/pubmed/31231243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.00700
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