Andersen–Tawil Syndrome Is Associated With Impaired PIP(2) Regulation of the Potassium Channel Kir2.1

Andersen–Tawil syndrome (ATS) type-1 is associated with loss-of-function mutations in KCNJ2 gene. KCNJ2 encodes the tetrameric inward-rectifier potassium channel Kir2.1, important to the resting phase of the cardiac action potential. Kir-channels’ activity requires interaction with the agonist phosp...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Handklo-Jamal, Reem, Meisel, Eshcar, Yakubovich, Daniel, Vysochek, Leonid, Beinart, Roy, Glikson, Michael, McMullen, Julie R., Dascal, Nathan, Nof, Eyal, Oz, Shimrit
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7243181/
https://ncbi.nlm.nih.gov/pubmed/32499698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00672
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