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Biochemical characterization and structural basis of reactivity and regioselectivity differences of Burkholderia thailandensis and Burkholderia glumae 1,6-didesmethyltoxoflavin N-methyltransferase

Burkholderia glumae converts the guanine base of guanosine triphosphate into an azapteridine and methylates both the pyrimidine and triazine rings to make toxoflavin. Strains of Burkholderia thailandensis and Burkholderia pseudomallei have a gene cluster encoding seven putative biosynthetic enzymes...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Fenwick, Michael K., Almabruk, Khaled H., Ealick, Steven E., Begley, Tadhg P., Philmus, Benjamin
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559721/
https://ncbi.nlm.nih.gov/pubmed/28665591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00476
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