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Biochemical characterization and structural basis of reactivity and regioselectivity differences of Burkholderia thailandensis and Burkholderia glumae 1,6-didesmethyltoxoflavin N-methyltransferase

Burkholderia glumae converts the guanine base of guanosine triphosphate into an azapteridine and methylates both the pyrimidine and triazine rings to make toxoflavin. Strains of Burkholderia thailandensis and Burkholderia pseudomallei have a gene cluster encoding seven putative biosynthetic enzymes...

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Bibliografske podrobnosti
izdano v:Biochemistry
Main Authors: Fenwick, Michael K., Almabruk, Khaled H., Ealick, Steven E., Begley, Tadhg P., Philmus, Benjamin
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559721/
https://ncbi.nlm.nih.gov/pubmed/28665591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00476
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