Hepatocyte-macrophage acetoacetate shuttle protects against tissue fibrosis

Metabolic plasticity has been linked to polarized macrophage function, but mechanisms connecting specific fuels to tissue macrophage function remain unresolved. Here we apply a stable isotope tracing, mass spectrometry-based untargeted metabolomics approach to reveal the metabolome penetrated by hep...

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Foilsithe in:Cell Metab
Main Authors: Puchalska, Patrycja, Martin, Shannon E., Huang, Xiaojing, Lengfeld, Justin E., Daniel, Bence, Graham, Mark J., Han, Xianlin, Nagy, Laszlo, Patti, Gary J., Crawford, Peter A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559243/
https://ncbi.nlm.nih.gov/pubmed/30449686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.10.015
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