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Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane

Rif1 is involved in telomere homeostasis, DNA replication timing, and DNA double-strand break (DSB) repair pathway choice from yeast to human. The molecular mechanisms that enable Rif1 to fulfill its diverse roles remain to be determined. Here, we demonstrate that Rif1 is S-acylated within its conse...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Fontana, Gabriele A., Hess, Daniel, Reinert, Julia K., Mattarocci, Stefano, Falquet, Benoît, Klein, Dominique, Shore, David, Thomä, Nicolas H., Rass, Ulrich
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6557901/
https://ncbi.nlm.nih.gov/pubmed/31182712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10349-z
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