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Whole genome bisulfite sequencing of Down syndrome brain reveals regional DNA hypermethylation and novel disorder insights

Down Syndrome (DS) is the most common genetic cause of intellectual disability, in which an extra copy of human chromosome 21 (HSA21) affects regional DNA methylation profiles across the genome. Although DNA methylation has been previously examined at select regulatory regions across the genome in a...

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Detalhes bibliográficos
Publicado no:Epigenetics
Main Authors: Laufer, Benjamin I., Hwang, Hyeyeon, Vogel Ciernia, Annie, Mordaunt, Charles E., LaSalle, Janine M.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6557615/
https://ncbi.nlm.nih.gov/pubmed/31010359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2019.1609867
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