Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6

PURPOSE: We previously reported that inhibitory G protein (G(i)) exerts intrinsic receptor-independent inhibitory activity upon adenylyl cyclase (AC) that regulates contractile force in rat ventricle. The two major subtypes of AC in the heart are AC5 and AC6. The aim of this study was to determine i...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Bull Melsom, Caroline, Cosson, Marie-Victoire, Ørstavik, Øivind, Lai, Ngai Chin, Hammond, H. Kirk, Osnes, Jan-Bjørn, Skomedal, Tor, Nikolaev, Viacheslav, Levy, Finn Olav, Krobert, Kurt Allen
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2019
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556981/
https://ncbi.nlm.nih.gov/pubmed/31173603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0218110
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