Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G(i)-dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle

BACKGROUND AND PURPOSE: β-Adrenoceptor (β-AR)-mediated inotropic effects are attenuated and G(i) proteins are up-regulated in heart failure (HF). Muscarinic receptors constitutively inhibit cAMP formation in normal rat cardiomyocytes. We determined whether constitutive activity of muscarinic recepto...

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Detalhes bibliográficos
Main Authors: Hussain, RI, Afzal, F, Mørk, HK, Aronsen, JM, Sjaastad, I, Osnes, J-B, Skomedal, T, Levy, FO, Krobert, KA
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042201/
https://ncbi.nlm.nih.gov/pubmed/21039419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01097.x
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