Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6

PURPOSE: We previously reported that inhibitory G protein (G(i)) exerts intrinsic receptor-independent inhibitory activity upon adenylyl cyclase (AC) that regulates contractile force in rat ventricle. The two major subtypes of AC in the heart are AC5 and AC6. The aim of this study was to determine i...

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Publicat a:PLoS One
Autors principals: Bull Melsom, Caroline, Cosson, Marie-Victoire, Ørstavik, Øivind, Lai, Ngai Chin, Hammond, H. Kirk, Osnes, Jan-Bjørn, Skomedal, Tor, Nikolaev, Viacheslav, Levy, Finn Olav, Krobert, Kurt Allen
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556981/
https://ncbi.nlm.nih.gov/pubmed/31173603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0218110
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