Direct measurements of VEGF–VEGFR2 binding affinities reveal the coupling between ligand binding and receptor dimerization

Vascular endothelial growth factor receptor 2 (VEGFR2) controls angiogenesis and is critically important for normal human development and cancer progression. A recent finding that VEGFR2 can dimerize in the absence of ligand raises the question whether VEGF binds to either VEGFR2 monomers or dimers...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: King, Christopher, Hristova, Kalina
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556587/
https://ncbi.nlm.nih.gov/pubmed/31023826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007737
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