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VEGFR-2 conformational switch in response to ligand binding
VEGFR-2 is the primary regulator of angiogenesis, the development of new blood vessels from pre-existing ones. VEGFR-2 has been hypothesized to be monomeric in the absence of bound ligand, and to undergo dimerization and activation only upon ligand binding. Using quantitative FRET and biochemical an...
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| Опубликовано в: : | eLife |
|---|---|
| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
eLife Sciences Publications, Ltd
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4829425/ https://ncbi.nlm.nih.gov/pubmed/27052508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13876 |
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