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Effect of the achondroplasia mutation on FGFR3 dimerization and FGFR3 structural response to fgf1 and fgf2: A quantitative FRET study in osmotically derived plasma membrane vesicles

The G380R mutation in the transmembrane domain of FGFR3 is a germline mutation responsible for most cases of Achondroplasia, a common form of human dwarfism. Here we use quantitative Föster Resonance Energy Transfer (FRET) and osmotically derived plasma membrane vesicles to study the effect of the a...

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Bibliografische gegevens
Gepubliceerd in:Biochim Biophys Acta
Hoofdauteurs: Sarabipour, Sarvenaz, Hristova, Kalina
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870120/
https://ncbi.nlm.nih.gov/pubmed/27040652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2016.03.027
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