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Mechanism of FGF receptor dimerization and activation
Fibroblast growth factors (fgfs) are widely believed to activate their receptors by mediating receptor dimerization. Here we show, however, that the FGF receptors form dimers in the absence of ligand, and that these unliganded dimers are phosphorylated. We further show that ligand binding triggers s...
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| Yayımlandı: | Nat Commun |
|---|---|
| Asıl Yazarlar: | , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4725768/ https://ncbi.nlm.nih.gov/pubmed/26725515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10262 |
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