Siglec-8 in eosinophilic disorders: receptor expression and targeting using chimeric antibodies

BACKGROUND: Sialic acid–binding immunoglobulin-like lectin (Siglec)-8 is selectively expressed on eosinophils, mast cells and basophils, and, when engaged on eosinophils, can cause cell death. OBJECTIVE: To characterize surface and soluble Siglec-8 levels in normal (ND) and eosinophilic (EO) subject...

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Veröffentlicht in:J Allergy Clin Immunol
Hauptverfasser: Legrand, Fanny, Cao, Yun, Wechsler, Joshua, Zhu, Xiang, Zimmermann, Nives, Rampertaap, Shakuntala, Monsale, Joseph, Romito, Kimberly, Youngblood, Bradford A., Brock, Emily C., Makiya, Michelle, Tomasevic, Nenad, Bebbington, Christopher, Maric, Irina, Metcalfe, Dean D., Bochner, Bruce S., Klion, Amy D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556424/
https://ncbi.nlm.nih.gov/pubmed/30543818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2018.10.066
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