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The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases

The 3′ poly(A) tail of mRNAs is fundamental to regulating eukaryotic gene expression. Shortening of the poly(A) tail, termed deadenylation, reduces transcript stability and inhibits translation. Nonetheless, the mechanism for poly(A) recognition by the conserved deadenylase complexes, Pan2–Pan3 and...

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Publicat a:Nat Struct Mol Biol
Autors principals: Tang, Terence TL, Stowell, James AW, Hill, Chris H, Passmore, Lori A
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555765/
https://ncbi.nlm.nih.gov/pubmed/31110294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0227-9
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