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The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases
The 3′ poly(A) tail of mRNAs is fundamental to regulating eukaryotic gene expression. Shortening of the poly(A) tail, termed deadenylation, reduces transcript stability and inhibits translation. Nonetheless, the mechanism for poly(A) recognition by the conserved deadenylase complexes, Pan2–Pan3 and...
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| Udgivet i: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6555765/ https://ncbi.nlm.nih.gov/pubmed/31110294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0227-9 |
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