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A Chemical Chaperone Decouples TDP-43 Disordered Domain Phase Separation from Fibrillation
Ribonucleoprotein (RNP) condensations through liquid-liquid phase separation play vital roles in the dynamic formation-dissolution of stress granules (SGs). These condensations are, however, usually assumed to be linked to pathologic fibrillation. Here, we show that physiologic condensation and path...
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| Pubblicato in: | Biochemistry |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6555487/ https://ncbi.nlm.nih.gov/pubmed/30520303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01051 |
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