A Chemical Chaperone Decouples TDP-43 Disordered Domain Phase Separation from Fibrillation

Ribonucleoprotein (RNP) condensations through liquid-liquid phase separation play vital roles in the dynamic formation-dissolution of stress granules (SGs). These condensations are, however, usually assumed to be linked to pathologic fibrillation. Here, we show that physiologic condensation and path...

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Vydáno v:Biochemistry
Hlavní autoři: Choi, Kyoung-Jae, Tsoi, Phoebe S., Moosa, Mahdi Muhammad, Paulucci-Holthauzen, Adriana, Jeff Liao, Shih-Chu, Ferreon, Josephine C., Ferreon, Allan Chris M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555487/
https://ncbi.nlm.nih.gov/pubmed/30520303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01051
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