OR22-6 Reversal Of Diet Induced Metabolic Syndrome In Mice With An Orally Active Small Molecule Inhibitor Of PAI-1

Plasminogen activator inhibitor 1 (PAI-1) is a member of the serpin family of proteases that inhibits tissue-type plasminogen activator and urokinase. Elevated levels of plasma PAI-1 are one of the hallmarks of obesity and are predictably elevated in patients with the metabolic syndrome and type 2 d...

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Bibliografiske detaljer
Udgivet i:J Endocr Soc
Main Authors: Levine, Joshua, Sun, Tianjiao, Eren, Mesut, Lux, Elizabeth, Miyata, Toshiyo, Barish, Grant, Douglas, Vaughan
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2019
Fag:
Diabetes Mellitus and Glucose Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554789/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-OR22-6
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