OR02-4 YAP1 Overexpression Associates With Worse Prognosis In Patients With Adrenal Tumors And YAP1 Inhibition By Verteporfin Reduces Tumorigenicity And Reverses Epithelial-mesenchymal Transition In Adrenocortical Tumor Cells

Background: There is no effective adjuvant therapy for patients with advanced adrenocortical tumors (ACT). Abnormal YAP1, a HIPPO pathway effector, is involved in some types of cancers. Recently, we showed association of the overexpression of YAP1 in pediatric ACT (pACT) with worse prognosis, but it...

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Veröffentlicht in:J Endocr Soc
Hauptverfasser: Bellido More, Candy, Bueno, Ana, De Castro, Margaret, Rauber Antonini, Sonir
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2019
Schlagworte:
Adrenal
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554785/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-OR02-4
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