Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis

BACKGROUND: To date, there is no effective therapy for patients with advanced/metastatic adrenocortical cancer (ACC). The activation of the Wnt/beta-catenin signaling is frequent in ACC and this pathway is a promising therapeutic target. AIM: To investigate the effects of the inhibition of the Wnt/b...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Leal, Letícia F., Bueno, Ana Carolina, Gomes, Débora C., Abduch, Rafael, de Castro, Margaret, Antonini, Sonir R.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767488/
https://ncbi.nlm.nih.gov/pubmed/26515592
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