SAT-353 The Synthetic Vitamin D Analog EB1089 Restricts Adrenocortical Tumor Proliferation in NCI-H295 Xenograft Model

The vitamin D (VD) receptor (VDR) is underexpressed in adult and pediatric adrenocortical tumors (ACT), especially in carcinomas (ACC). VDR activation by VD represses B-catenin signaling in different types of tumors that like ACT, present aberrant B-catenin expression. EB1089 is a potent synthetic V...

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Bibliographic Details
Published in:J Endocr Soc
Main Authors: Bueno, Ana, More, Candy, Ramalho, Fernando, Moreira, Ayrton, De Castro, Margaret, Rauber Antonini, Sonir
Format: Artigo
Language:Inglês
Published: Endocrine Society 2019
Subjects:
Adrenal
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6552194/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-SAT-353
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