Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia

Relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) has a dismal outcome, and no effective targeted immunotherapies for T-ALL exist. The extension of chimeric antigen receptor (CAR) T cells (CARTs) to T-ALL remains challenging because the shared expression of target antigens between CART...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Sánchez-Martínez, Diego, Baroni, Matteo L., Gutierrez-Agüera, Francisco, Roca-Ho, Heleia, Blanch-Lombarte, Oscar, González-García, Sara, Torrebadell, Montserrat, Junca, Jordi, Ramírez-Orellana, Manuel, Velasco-Hernández, Talía, Bueno, Clara, Fuster, José Luís, Prado, Julia G., Calvo, Julien, Uzan, Benjamin, Cools, Jan, Camos, Mireia, Pflumio, Françoise, Toribio, María Luisa, Menéndez, Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Immunobiology and Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554538/
https://ncbi.nlm.nih.gov/pubmed/30796021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-10-882944
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