C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases

C3 glomerulopathy (C3G) is a severe kidney disease, which is caused by defective regulation of the alternative complement pathway. Disease pathogenesis is heterogeneous and is caused by both autoimmune and genetic factors. Here we characterized IgG autoantibodies derived from 33 patients with autoim...

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Vydáno v:Front Immunol
Hlavní autoři: Zhao, Fei, Afonso, Sara, Lindner, Susanne, Hartmann, Andrea, Löschmann, Ina, Nilsson, Bo, Ekdahl, Kristina N., Weber, Lutz T., Habbig, Sandra, Schalk, Gesa, Kirschfink, Michael, Zipfel, Peter F., Skerka, Christine
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554336/
https://ncbi.nlm.nih.gov/pubmed/31214159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01030
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