Improved Efficacy and Reduced Toxicity Using a Custom-Designed Irinotecan-Delivering Silicasome for Orthotopic Colon Cancer

Irinotecan is a key chemotherapeutic agent for the treatment of colorectal (CRC) and pancreatic (PDAC) cancer. Because of a high incidence of bone marrow and gastrointestinal (GI) toxicity, Onivyde® (a liposome) was introduced to provide encapsulated irinotecan (Ir) delivery in PDAC patients. While...

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Bibliographic Details
Published in:ACS Nano
Main Authors: Liu, Xiangsheng, Jiang, Jinhong, Chan, Ryan, Ji, Ying, Lu, Jianqin, Liao, Yu-Pei, Okene, Michael, Lin, Joshua, Lin, Paulina, Chang, Chong Hyun, Wang, Xiang, Tang, Ivanna, Zheng, Emily, Qiu, Waveley, Wainberg, Zev A., Nel, Andre E., Meng, Huan
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554030/
https://ncbi.nlm.nih.gov/pubmed/30525443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.8b06164
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