SAT-354 Characterization of Cell Death Induced by SOAT1 Inhibition in Adrenocortical Carcinoma Cells

Background: Mitotane is the only drug approved for treatment of adrenocortical carcinoma (ACC). We have found that mitotane inhibits Sterol-O-Acyl transferase 1 (SOAT1) which leads to depletion of cholesterol esters and increase of free cholesterol in the ACC cell line NCI-H295. We demonstrated acti...

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Bibliographic Details
Published in:J Endocr Soc
Main Authors: Weigand, Isabel, Schreiner, Jochen, Roehrig, Florian, Hoefner, Kerstin, Kendl, Sabine, Fassnacht, Martin, Sbiera, Silviu, Kroiss, Matthias
Format: Artigo
Language:Inglês
Published: Endocrine Society 2019
Subjects:
Adrenal
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6552647/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-SAT-354
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