Elevated O-GlcNAcylation enhances pro-inflammatory Th17 function by altering the intracellular lipid microenvironment

Chronic, low-grade inflammation increases the risk for atherosclerosis, cancer, and autoimmunity in diseases such as obesity and diabetes. Levels of CD4(+) T helper 17 (Th17) cells, which secrete interleukin 17A (IL-17A), are increased in obesity and contribute to the inflammatory milieu; however, t...

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Vydáno v:J Biol Chem
Hlavní autoři: Machacek, Miranda, Saunders, Harmony, Zhang, Zhen, Tan, Ee Phie, Li, Jibiao, Li, Tiangang, Villar, Maria T., Artigues, Antonio, Lydic, Todd, Cork, Gentry, Slawson, Chad, Fields, Patrick E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Glycobiology and Extracellular Matrices
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6552434/
https://ncbi.nlm.nih.gov/pubmed/31010828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008373
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