Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling–activated Src maintains cholesterol levels and protects from atherosclerosis

The bile acid (BA) nuclear receptor, farnesoid X receptor (FXR/NR1H4), maintains metabolic homeostasis by transcriptional control of numerous genes, including an intestinal hormone, fibroblast growth factor-19 (FGF19; FGF15 in mice). Besides activation by BAs, the gene-regulatory function of FXR is...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Byun, Sangwon, Jung, Hyunkyung, Chen, Jinjing, Kim, Young-Chae, Kim, Dong-Hyun, Kong, Bo, Guo, Grace, Kemper, Byron, Kemper, Jongsook Kim
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6552419/
https://ncbi.nlm.nih.gov/pubmed/30996006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008360
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