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Detection and Quantification of 4-Hydroxy-1-(3-pyridyl)-1-butanone (HPB) from Smoker Albumin and its Potential as a Surrogate Biomarker of Tobacco-Specific Nitrosamines Exposure and Bioactivation
4-(Methylnitrosamino)-l-(3-pyridyl)-1-butanone (NNK) and N-nitrosonornicotine (NNN), two tobacco specific nitrosamine carcinogens, can form adducts with DNA and proteins via pyridyloxobutylation upon phase I enzyme-mediated bioactivation. Such DNA modifications have been proposed as the root cause t...
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| Udgivet i: | Toxicol Lett |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6551521/ https://ncbi.nlm.nih.gov/pubmed/31026483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2019.04.020 |
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