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Detection and Quantification of 4-Hydroxy-1-(3-pyridyl)-1-butanone (HPB) from Smoker Albumin and its Potential as a Surrogate Biomarker of Tobacco-Specific Nitrosamines Exposure and Bioactivation

4-(Methylnitrosamino)-l-(3-pyridyl)-1-butanone (NNK) and N-nitrosonornicotine (NNN), two tobacco specific nitrosamine carcinogens, can form adducts with DNA and proteins via pyridyloxobutylation upon phase I enzyme-mediated bioactivation. Such DNA modifications have been proposed as the root cause t...

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Bibliografiske detaljer
Udgivet i:Toxicol Lett
Main Authors: Wang, Yi, Narayanapillai, Sreekanth Chanickal, Hu, Qi, Fujioka, Naomi, Xing, Chengguo
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551521/
https://ncbi.nlm.nih.gov/pubmed/31026483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2019.04.020
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