Transcytosis maintains CFTR apical polarity in the face of constitutive and mutation-induced basolateral missorting

Apical polarity of cystic fibrosis transmembrane conductance regulator (CFTR) is essential for solute and water transport in secretory epithelia and can be impaired in human diseases. Maintenance of apical polarity in the face of CFTR non-polarized delivery and inefficient apical retention of mutant...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Bidaud-Meynard, Aurélien, Bossard, Florian, Schnúr, Andrea, Fukuda, Ryosuke, Veit, Guido, Xu, Haijin, Lukacs, Gergely L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6550009/
https://ncbi.nlm.nih.gov/pubmed/30975917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.226886
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