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High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity

Therapeutic developments for neurodegenerative disorders are redirecting their focus to the mechanisms that contribute to neuronal connectivity and the loss thereof. Using a high-throughput microscopy pipeline that integrates morphological and functional measurements, we found that inhibition of dua...

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Dades bibliogràfiques
Publicat a:Acta Neuropathol Commun
Autors principals: Verschuuren, Marlies, Verstraelen, Peter, García-Díaz Barriga, Gerardo, Cilissen, Ines, Coninx, Emma, Verslegers, Mieke, Larsen, Peter H., Nuydens, Rony, De Vos, Winnok H.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549294/
https://ncbi.nlm.nih.gov/pubmed/31164177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0741-3
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