High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity

Therapeutic developments for neurodegenerative disorders are redirecting their focus to the mechanisms that contribute to neuronal connectivity and the loss thereof. Using a high-throughput microscopy pipeline that integrates morphological and functional measurements, we found that inhibition of dua...

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Udgivet i:Acta Neuropathol Commun
Main Authors: Verschuuren, Marlies, Verstraelen, Peter, García-Díaz Barriga, Gerardo, Cilissen, Ines, Coninx, Emma, Verslegers, Mieke, Larsen, Peter H., Nuydens, Rony, De Vos, Winnok H.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Methodology Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549294/
https://ncbi.nlm.nih.gov/pubmed/31164177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0741-3
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