High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity

Therapeutic developments for neurodegenerative disorders are redirecting their focus to the mechanisms that contribute to neuronal connectivity and the loss thereof. Using a high-throughput microscopy pipeline that integrates morphological and functional measurements, we found that inhibition of dua...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Acta Neuropathol Commun
Prif Awduron: Verschuuren, Marlies, Verstraelen, Peter, García-Díaz Barriga, Gerardo, Cilissen, Ines, Coninx, Emma, Verslegers, Mieke, Larsen, Peter H., Nuydens, Rony, De Vos, Winnok H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2019
Pynciau:
Methodology Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549294/
https://ncbi.nlm.nih.gov/pubmed/31164177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0741-3
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