PARP inhibitor efficacy depends on CD8+ T cell recruitment via intratumoral STING pathway activation in BRCA-deficient models of triple-negative breast cancer

Combinatorial clinical trials of PARP inhibitors with immunotherapies are ongoing, yet the immunomodulatory effects of PARP inhibition have been incompletely studied. Here, we sought to dissect the mechanisms underlying PARP inhibitor-induced changes in the tumor microenvironment of BRCA1-deficient...

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Dettagli Bibliografici
Pubblicato in:Cancer Discov
Autori principali: Pantelidou, Constantia, Sonzogni, Olmo, De Oliveria Taveira, Mateus, Mehta, Anita K., Kothari, Aditi, Wang, Dan, Visal, Tanvi, Li, Michelle K., Pinto, Jocelin, Castrillon, Jessica A., Cheney, Emily M., Bouwman, Peter, Jonkers, Jos, Rottenberg, Sven, Guerriero, Jennifer L., Wulf, Gerburg M., Shapiro, Geoffrey I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548644/
https://ncbi.nlm.nih.gov/pubmed/31015319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1218
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