Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer

Despite objective responses to PARP inhibition and improvements in progression-free survival compared to standard chemotherapy in patients with BRCA-associated triple-negative breast cancer (TNBC), benefits are transitory. Using high dimensional single-cell profiling of human TNBC, here we demonstra...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nat Cancer
मुख्य लेखकों: Mehta, Anita K., Cheney, Emily M., Hartl, Christina A., Pantelidou, Constantia, Oliwa, Madisson, Castrillon, Jessica A., Lin, Jia-Ren, Hurst, Katie E., de Oliveira Taveira, Mateus, Johnson, Nathan T., Oldham, William M., Kalocsay, Marian, Berberich, Matthew J., Boswell, Sarah A., Kothari, Aditi, Johnson, Shawn, Dillon, Deborah A., Lipschitz, Mikel, Rodig, Scott, Santagata, Sandro, Garber, Judy E., Tung, Nadine, Yélamos, José, Thaxton, Jessica E., Mittendorf, Elizabeth A., Sorger, Peter K., Shapiro, Geoffrey I., Guerriero, Jennifer L.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2020
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7963404/
https://ncbi.nlm.nih.gov/pubmed/33738458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-020-00148-7
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