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Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer
Despite objective responses to PARP inhibition and improvements in progression-free survival compared to standard chemotherapy in patients with BRCA-associated triple-negative breast cancer (TNBC), benefits are transitory. Using high dimensional single-cell profiling of human TNBC, here we demonstra...
שמור ב:
| הוצא לאור ב: | Nat Cancer |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2020
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7963404/ https://ncbi.nlm.nih.gov/pubmed/33738458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-020-00148-7 |
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