Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer

Despite objective responses to PARP inhibition and improvements in progression-free survival compared to standard chemotherapy in patients with BRCA-associated triple-negative breast cancer (TNBC), benefits are transitory. Using high dimensional single-cell profiling of human TNBC, here we demonstra...

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Udgivet i:Nat Cancer
Main Authors: Mehta, Anita K., Cheney, Emily M., Hartl, Christina A., Pantelidou, Constantia, Oliwa, Madisson, Castrillon, Jessica A., Lin, Jia-Ren, Hurst, Katie E., de Oliveira Taveira, Mateus, Johnson, Nathan T., Oldham, William M., Kalocsay, Marian, Berberich, Matthew J., Boswell, Sarah A., Kothari, Aditi, Johnson, Shawn, Dillon, Deborah A., Lipschitz, Mikel, Rodig, Scott, Santagata, Sandro, Garber, Judy E., Tung, Nadine, Yélamos, José, Thaxton, Jessica E., Mittendorf, Elizabeth A., Sorger, Peter K., Shapiro, Geoffrey I., Guerriero, Jennifer L.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7963404/
https://ncbi.nlm.nih.gov/pubmed/33738458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-020-00148-7
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