PARP inhibitor efficacy depends on CD8+ T cell recruitment via intratumoral STING pathway activation in BRCA-deficient models of triple-negative breast cancer

Combinatorial clinical trials of PARP inhibitors with immunotherapies are ongoing, yet the immunomodulatory effects of PARP inhibition have been incompletely studied. Here, we sought to dissect the mechanisms underlying PARP inhibitor-induced changes in the tumor microenvironment of BRCA1-deficient...

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Vydáno v:Cancer Discov
Hlavní autoři: Pantelidou, Constantia, Sonzogni, Olmo, De Oliveria Taveira, Mateus, Mehta, Anita K., Kothari, Aditi, Wang, Dan, Visal, Tanvi, Li, Michelle K., Pinto, Jocelin, Castrillon, Jessica A., Cheney, Emily M., Bouwman, Peter, Jonkers, Jos, Rottenberg, Sven, Guerriero, Jennifer L., Wulf, Gerburg M., Shapiro, Geoffrey I.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548644/
https://ncbi.nlm.nih.gov/pubmed/31015319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1218
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